Have you just installed AMD Catalyst Control Center and when you want to open it, mouse changes to “in progress” indicator and then nothing happens? If you check the Event Viewer, KERNELBASE.DLL and CLI.exe errors for AMD stuff, it’s not .NET Framework issue at all. I thought this first as well, but after checking if I have latest version and verifying system integrity (I just made a WIn8.1 system Refresh to clean it up) with sfc /scannow and all was well. Catalyst drivers out of the blue on a perfectly clean system decided to go haywire. Tried reinstalling them several times, deleting them by hand in Device Manager, nothing.
Solution? Only way to do it was to use AMD Driver Cleaner located here:
Uninstalled the drivers with the above tool, re-downloaded latest WHQL drivers and after that, Catalyst Control Center was working fine again. Just another day in systems hell…